The player fights mutated human enemies in first person with firearms, a melee drill and genetic powers; kills produce heavy blood spray and corpses that remain in the environment.
The player can drink liquor and smoke cigarettes scavenged in the world for a small gameplay effect, and injects gene-altering plasmids by needle as a core mechanic.
The story turns on orphaned girls surgically implanted to harvest a drug from corpses, and the player repeatedly chooses whether to rescue these children or lethally harvest them for their material.
Enemies and many corpses throughout the city are grotesquely disfigured and mutated as subject matter (body horror), beyond ordinary combat damage.
Splicer enemies and recorded audio diaries use strong profanity, including 'fuck'.
Disfigured enemies ambush the player through a decaying undersea city, and a fast, aggressive Big Sister hunts the player in scripted encounters.
Rapture's collapse into a lawless criminal underworld (smuggling, gang war, murder) is depicted throughout the setting and audio diaries.
A district built around a former brothel is explored and diaries reference the sex work once conducted there; the player cannot solicit or engage.
Audio logs and the Siren Alley red-light district reference sex and Rapture's former escort trade in dialogue and posters; nothing sexual is shown.
BioShock 2 is a first-person shooter set roughly a decade after the first game in the ruined underwater city of Rapture. The player takes the role of an early Big Daddy prototype searching the flooded, decayed city while fighting mutated human enemies called Splicers using firearms, a heavy melee drill, and genetic superpowers called plasmids. Combat is bloody, with visible wounds and corpses. The setting is heavy with distressing subject matter: addiction to a gene-altering substance, a society that collapsed into a gang war, and orphaned girls surgically converted into 'Little Sisters' who harvest material from the dead — whom the player can choose to rescue or kill for resources. There is strong profanity, references to Rapture's former red-light district and sex trade, drinking, smoking, and the constant use of injected drugs for powers. The atmosphere leans into survival horror, with ambushes and pursuing enemies.
The game frames its violence and drug use through a bleak dystopian lens, using Rapture's ruin to examine unchecked ideology, addiction, and the exploitation of children. The central recurring choice — to rescue the Little Sisters or harvest them for greater power — is presented as a genuine moral test, with the narrative rewarding mercy in its endings; the game invites reflection on that choice rather than celebrating harm.
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